Scripps Research scientists sent stem-cell-derived brain organoids to the ISS to study the effects of microgravity on brain cells, finding that the organoids matured faster and showed signs of specialization compared to Earth-grown controls. The findings have been published in the journal Stem Cells Translational Medicine. Phys.Org reports: To examine how the space environment impacts cellular functions, the team compared the cells' RNA expression patterns -- a measure of gene activity -- to identical "ground control" organoids that had remained on Earth. Surprisingly, they found that the organoids grown in microgravity had higher levels of genes associated with maturity and lower levels of genes associated with proliferation compared to the ground controls, meaning that the cells exposed to microgravity developed faster and replicated less than those on Earth. "We discovered that in both types of organoids, the gene expression profile was characteristic of an older stage of development than the ones that were on the ground," [says co-senior author Jeanne Loring, Ph.D., professor emeritus in the Department of Molecular Medicine and founding director of the Center for Regenerative Medicine at Scripps Research]. "In microgravity, they developed faster, but it's really important to know these were not adult neurons, so this doesn't tell us anything about aging."...
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