alternative_right shares a report from Phys.org: It is known in the scientific community that if you have a self-sustained oscillation, such as an arteriole, and you add an external stimulus at a similar but not identical frequency, you can lock the two, meaning you can shift the frequency of the oscillator to that of the external stimulus. In fact, it has been shown that if you connect two clocks, they will eventually synchronize their ticking. Distinguished Professor of Physics and Neurobiology David Kleinfeld found that if he applied an external stimulus to a neuron, the entire vasculature would lock at the same frequency. However, if he stimulated two sets of neurons at two different frequencies, something unexpected happened: some arterioles would lock at one frequency and others would lock at another frequency, forming a staircase effect.
Searching for an explanation, Kleinfeld enlisted the help of his colleague, Professor of Physics Massimo Vergassola, who specializes in understanding the physics of living systems, and then recruited Ecole Normale Superieure graduate student Marie Sellier-Prono and Senior Researcher at the Institute for Complex Systems Massimo Cencini. Together, the researchers found they could use a classical model of coupled oscillators with an intestinal twist. The gut oscillates naturally due to peristalsis -- the contracting and relaxing of muscles in the digestive tract -- and provided a simplified model over the complex network of blood vessels in the brain. The intestine is unidirectional, meaning frequencies shift in one direction in a gradient from higher to lower. This is what enables food to move in one direction from the beginning of the small intestine to the end of the large intestine.
"Coupled oscillators talk to each other and each section of the intestine is an oscillator that talks to the other sections near it," stated Vergassola. "Normally, coupled oscillators are studied in a homogeneous setting, meaning all the oscillators are at more or less similar frequencies. In our case, the oscillators were more varied, just as in the intestine and the brain." In studying the coupled oscillators in the gut, past researchers observed that there is indeed a staircase effect where similar frequencies lock onto those around it, allowing for the rhythmic movement of food through the digestive tract. But the height of the rises or breaks, the length of the stair runs or frequencies, and the conditions under which the staircase phenomenon occurred -- essential features of biological systems -- was something which had not been determined until now. The findings have been published in the journal Physical Review Letters.
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